Publication: lmmunohistochemical study of p53 expression in cancer tissues from patients undergoing radiation therapy
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Date
1995
Authors
Hamada, N. ; Ogawal, Y. ; Seguchi, H. ; Terashima, M. ; Nishioka, A. ; Inomata, T. ; Yoshida, S. ; Kishimoto, S. ; Saito, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Immunostaining using p53 monoclonal
antibodies (p53(Ab-3) recognizes mutant type and
p53(Ab-6) the wild type of p53 protein) was performed
on frozen sections of biopsy specimens obtained before
and during preoperative radiotherapy from 23 patients
with head and neck squamous cell carcinoma. The
positive staining rates of p53(Ab-3) before radiotherapy
and at radiation doses of 4Gy, lOGy and 20Gy were
30.0%, 38.9%, 25.0% and 6.25%, and those of p53(Ab-
6) 10,5%, 11.8%, 5.0% and 0% respectively. The
relationship between the immunohistochemical findings
and antitumor effect at radiation dose of 20Gy was
examined on the correspondent haematoxylin-eosin
sections. In patients whose p53(Ab-3) stainings were
positive at any doses of radiotherapy, the antitumor
effect at the cumulative dose of 20Gy was either
remarkable or effective. Moreover, the frequency of the
expression of mutant type p53 protein tended to increase
in rather radiosensitive tumors. As for wild type p53
protein, there was no remarkable relationship between
the staining of p53(Ab-6) and the antitumor effect.
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