Publication: Immunohistochemical analysis of CD146 expression in canine skin tumours
Authors
Abou Asa, S. ; Anwar, Sh. ; Yanai, T. ; Sakai, H.
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Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
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DOI
DOI: 10.14670/HH-11-690
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info:eu-repo/semantics/article
Description
Abstract
CD146, a cell adhesion molecule, is
overexpressed in a variety of carcinomas, including
melanoma, prostate cancer, epithelial ovarian cancer, and
breast cancer. The level of expression is directly
correlated with tumour progression and metastatic
potential. The most commonly affected organ for both
neoplastic and non-neoplastic tumours is the skin. The
objective of this study is to investigate the
immunohistochemical expression of CD146 in canine
skin tumours of epidermal or follicular origin in 53
squamous cell carcinomas (SCCs), 9 squamous
papillomas, 7 infundibular keratinizing acanthomas
(IKA), 21 trichoepitheliomas, 13 trichoblastomas, and 3
pilomatricomas. Immunohistochemical results showed
that SCCs (90.6%), squamous papilloma (33.3%), IKA
(85.7%), trichoepithelioma (85.9%), trichoblastoma
(30.8%) and pilomatricoma (100%), respectively, were
positive for CD146. The significant expression of
CD146 in SCCs supports its importance as a useful
treatment target. CD146 could also be used in
differentiation of trichoepithelioma and trichoblastoma.
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