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Serotonin-producing pancreatic endocrine tumour. Histological, ultrastructural and immunohistochemical study of a case

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dc.contributor.authorKanavaros, Panagiotises
dc.contributor.authorHoang, Catherinees
dc.contributor.authorLe Bodic, Marie Francoise
dc.contributor.authorPolivka, Marc
dc.contributor.authorHautefeuille, Pierre
dc.date.accessioned2011-02-01T08:44:53Z
dc.date.available2011-02-01T08:44:53Z
dc.date.issued1990
dc.description.abstractSerotonin-producing pancreatic endocrine tumours are rare neoplasms which in most cases exhibit malignant biological behaviour. These tumours, in the majority of the well-documented cases, are composed of argyrophil- and argentaffin-positive cells which contain large pleomorphic neurosecretory granules. In contrast, argyrophilic non-argentaffin pancreatic endocrine tumours with tumour cells containing round neurosecretory granules are exceptional. In this study we describe such a tumour not associated with clinical evidence of carcinoid syndrome in a 60-year-old woman. Histological examination revealed tumour extension in pancreatic lymphatic vessels and veins but no evidence of locoregional or distant metastases. Ten months after surgery the patient showed no recurrence of the disease. Immunohistochernistry revealed cytoplasmic serotonin production in the tumour cells which were negative for anti-gastrin, insulin, glucagon, somatostatin, pancreatic polypeptide (PP), vasoactive intestinal peptide (VIP) and ACTH. This study emphasizes the usefulness of combined ultrastructural and immunohistochemical investigations in order to identify and characterize the rare pancreatic endocrine tumours with serotonin production.es
dc.formatapplication/pdfes
dc.format.extent4es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/18180
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectImmunohistochemistryes
dc.subjectSerotonines
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleSerotonin-producing pancreatic endocrine tumour. Histological, ultrastructural and immunohistochemical study of a casees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol. 5, nº 3 (1990)