Publication: Serotonin-producing pancreatic endocrine tumour. Histological, ultrastructural and immunohistochemical study of a case
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Date
1990
Authors
Kanavaros, Panagiotis ; Hoang, Catherine ; Le Bodic, Marie Francoise ; Polivka, Marc ; Hautefeuille, Pierre
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Serotonin-producing pancreatic endocrine
tumours are rare neoplasms which in most cases exhibit
malignant biological behaviour. These tumours, in the
majority of the well-documented cases, are composed
of argyrophil- and argentaffin-positive cells which
contain large pleomorphic neurosecretory granules. In
contrast, argyrophilic non-argentaffin pancreatic
endocrine tumours with tumour cells containing round
neurosecretory granules are exceptional. In this study we
describe such a tumour not associated with clinical
evidence of carcinoid syndrome in a 60-year-old woman.
Histological examination revealed tumour extension in
pancreatic lymphatic vessels and veins but no evidence of
locoregional or distant metastases. Ten months after
surgery the patient showed no recurrence of the disease.
Immunohistochernistry revealed cytoplasmic serotonin
production in the tumour cells which were negative for
anti-gastrin, insulin, glucagon, somatostatin, pancreatic
polypeptide (PP), vasoactive intestinal peptide (VIP)
and ACTH. This study emphasizes the usefulness of
combined ultrastructural and immunohistochemical
investigations in order to identify and characterize the
rare pancreatic endocrine tumours with serotonin
production.
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