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Título: | Quantitative cell-cycle protein expression in oral cancer assessed by computer-assisted system |
Fecha de publicación: | 2006 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología |
Palabras clave: | Oral cancer PCNA |
Resumen: | The knowledge of cell-cycle control has shown that the capacity of malignant growth is acquired by the stepwise accumulation of defects in specific genes regulating cell growth. Histologic diagnosis might be improved by a quantitative evaluation of more specific diagnosis biomarkers, which could help to precisely identify pre-malignant and malignant oral lesions. The aim of the present study is to evaluate whether computer-based quantitative assessment of p53, PCNA and Ki-67 immunohistochemical expression, could be used clinically to foresee the risk of oral malignant transformation. This retrospective study was carried out in ninety-five oral biopsies, 27 were classified as fibrous inflammatory hyperplasia, 40 as leukoplakia and 28 as oral squamous cell carcinoma. Sixteen out of the 40 leukoplakia were diagnosed as non-dysplastic leukoplakia, the other 24 being dysplastic leukoplakia, of which 50.0% were classified as moderate to severe dysplasia. Comparison of the four groups of oral tissues showed significant rises in p53 and Ki-67 positivity index, which increased steadily in the order benign, premalignant, and malignant. In contrast, it was not possible to relate higher PCNA levels with pre-malignant and malignant oral lesions. We therefore conclude that PCNA immunohistochemistry expression is probably an inappropriate marker to identify oral carcinogenesis, whereas joint quantitative evaluation of p53 and Ki-67, appears to be useful as a tumor marker, providing a prediagnostic estimate of the potential for cell-cycle deregulation of the oral proliferate status. |
Autor/es principal/es: | Soares, C.P. Zuanon, J.A.S. Teresa, D.B. Fregonezi, P.A. Neto, C.B. Oliveira, M.R.B. Donadi, E.A. Martinelli-Kläy, C.P. Soares, E.G. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/22681 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 8 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.21, nº 7 (2006) |
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Quantitative cellcycle protein expression in oral cancer....pdf | 4,63 MB | Adobe PDF | Visualizar/Abrir |
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