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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Soares, C.P. | es |
dc.contributor.author | Zuanon, J.A.S. | es |
dc.contributor.author | Teresa, D.B. | - |
dc.contributor.author | Fregonezi, P.A. | - |
dc.contributor.author | Neto, C.B. | - |
dc.contributor.author | Oliveira, M.R.B. | - |
dc.contributor.author | Donadi, E.A. | - |
dc.contributor.author | Martinelli-Kläy, C.P. | - |
dc.contributor.author | Soares, E.G. | - |
dc.date.accessioned | 2011-06-30T12:03:11Z | - |
dc.date.available | 2011-06-30T12:03:11Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0213-3911 | es |
dc.identifier.uri | http://hdl.handle.net/10201/22681 | - |
dc.description.abstract | The knowledge of cell-cycle control has shown that the capacity of malignant growth is acquired by the stepwise accumulation of defects in specific genes regulating cell growth. Histologic diagnosis might be improved by a quantitative evaluation of more specific diagnosis biomarkers, which could help to precisely identify pre-malignant and malignant oral lesions. The aim of the present study is to evaluate whether computer-based quantitative assessment of p53, PCNA and Ki-67 immunohistochemical expression, could be used clinically to foresee the risk of oral malignant transformation. This retrospective study was carried out in ninety-five oral biopsies, 27 were classified as fibrous inflammatory hyperplasia, 40 as leukoplakia and 28 as oral squamous cell carcinoma. Sixteen out of the 40 leukoplakia were diagnosed as non-dysplastic leukoplakia, the other 24 being dysplastic leukoplakia, of which 50.0% were classified as moderate to severe dysplasia. Comparison of the four groups of oral tissues showed significant rises in p53 and Ki-67 positivity index, which increased steadily in the order benign, premalignant, and malignant. In contrast, it was not possible to relate higher PCNA levels with pre-malignant and malignant oral lesions. We therefore conclude that PCNA immunohistochemistry expression is probably an inappropriate marker to identify oral carcinogenesis, whereas joint quantitative evaluation of p53 and Ki-67, appears to be useful as a tumor marker, providing a prediagnostic estimate of the potential for cell-cycle deregulation of the oral proliferate status. | es |
dc.format | application/pdf | es |
dc.format.extent | 8 | es |
dc.language | eng | es |
dc.publisher | Murcia : F. Hernández | es |
dc.relation.ispartof | Histology and histopathology | es |
dc.rights | info:eu-repo/semantics/openAccess | es |
dc.subject | Oral cancer | es |
dc.subject | PCNA | es |
dc.subject.other | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología | es |
dc.title | Quantitative cell-cycle protein expression in oral cancer assessed by computer-assisted system | es |
dc.type | info:eu-repo/semantics/article | es |
Aparece en las colecciones: | Vol.21, nº 7 (2006) |
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Quantitative cellcycle protein expression in oral cancer....pdf | 4,63 MB | Adobe PDF | Visualizar/Abrir |
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