Histology and histopathology Vol. 9, nº 2 (1994)
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- PublicationOpen AccessThe fate of the luminal asymmetric unit membrane of the superficial cell of the rat transitional epithelium(Murcia: F. Hernández, 1994) Zhang, S.X.; Seguchi, H.The fate of the luminal asymmetric unit membrane (AUM) of the superficial cell of the transitional epithelium of the rat urinary bladder was electron microscopically and cytochemically investigated using exogenously administered horseradish peroxidase (HRP) as tracer. HRP-positive discoidal vesicles were formed by the folding of the AUM of the luminal surface plasma membrane. With the passage of time, these vesicles changed their shapes and were finally transformed into lysosomes by the following possible routes: 1) by becoming multivesicular bodies (MVBs); 2) by directly fusing with lysosomes; and 3) by becoming autophagic vacuoles. Another possibility would be reutilization.
- PublicationOpen AccessInvited Review: 65Zn in studies of neurobiology of Zinc(Murcia : F. Hernández, 1994) Vera-Gil, A.; Perez-Castejon, M.C.The presence of Zinc in the mossy fibre system of the Hippocampi~s is the most thoroughly studied of Zinc relation to the CNS, but many other areas of the CNS are Zinc-containing. Many methods have been used in order to investigate the above mentioned relation, most of then1 being based on histochemistry and physical measurement. 6 5 ~ tnra ce has also been used, but scarcely, probably due to the ciifficulty of radioisotope handling. In the present review we focus on 6 5 ~ nst udies i n the CNS and comment on their advantages and disadvantages.
- PublicationOpen AccessImmunohistochemicaI-morphometric study of the LH-adenohypophyseal cells following chronic treatment with met-enkephalin(Murcia : F. Hernández, 1994) Rubio, M.; Sanchez, F.; Carretero, J.; Riesco, J. M.; Cabo, L.; Vazquez, R.In order to test the possible effect of chronic treatment with met-enkephalin upon the LHadenohypophyseal cells, an imrnunohistochemicalmorphometric study was carried out in rats of both sexes receiving a daily dose of 40 pg of met-enkephalin intramuscularly over 15 days. Following the administration of the opioid, a drastic decrease in the cellular, cytoplasmic and nuclear areas when compared to the normal and control animals was detected. Morphologically, the main finding in males was the appearance of irregularly-shaped pseudovacuolated cells. On the other hand, in females a decrease in the intensity of reaction was found. These results strongly suggest a decrease in the activity of the LH-adenohypophyseal cells following chronic administration of met-enkephalin.
- PublicationOpen AccessTransitional papillary cell carcinoma of the ureter, a histological and ultrastructural study(Murcia : F. Hernández, 1994) Melis, M.; Petrozza, V.; Pulvirenti, S.; Eleuteri, E.; Mosca, A.; Angelini, L.; Carpino, F.We report a case of transitional papillary carcinoma of the distal left ureter. The histological and ultrastructural features were seen and compared by SEM and TEM. Observations confirm the data of literature that the deep cells of neoplasm are a normal morphological finding while the superficial cells do not have the characteristics present in normal transitional cells. In addition, SEM shows small groups or single cells with ccpleomorphic microvilli>, on the cell surface. These, in ureter, confirm the studies of many authors who have observed these abnormalities in carcinomas of several organs like breast, colon, liver and mesothelium.
- PublicationOpen AccessMorphology and changes in Clara cells in the foetal bronchioles of Swiss mice(Murcia : F. Hernández, 1994) Blanco, A.; Mendez, A.; Carrasco, L.; Bautista, María José; Sierra, M. A.In this work we have studied the morphology and evolution of Clara cells in the bronchiolar mucosa of lungs from 63 Swiss mice foetuses that were classified into three groups according to age (14, 16 and 18 days). A control group composed of 21 15-day-old Swiss mice was also studied. The most salient feature of the Clara cells observed was the occurrence of two types of secretory granules and a large smooth endoplasmic reticulum . On the other hand, the Clara cells of the control group had a single secretory granule. Clara cells thus seem to take part in bronchiolar metabolism, as they were quite abundant in the early foetal groups and diminished as birth approached. This cell decrease was confirmed by the control group (15- day-old mice), the bronchioles of which contained scant cells and numerous ciliated cells.