Browsing by Subject "S-100 protein"

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    A histological study of the Shionogi adenocarcinoma 115 grown in male and female mice
    (Murcia : F. Hernández, 1990) Rowse, Guerry J.; Rowan, Rosemary E.; Worth, Ann J.; Reid, Phil E.; Weinberg, Joanne; Emerman, Joanne T.
    We have previously demonstrated that growth rate and morphology differ between androgenresponsive Shionogi mouse mammary tumours maintained in male and female mice. Furthermore, we can modulate the growth rate of these tumours in male mice by exposing the mice to psychosocial stressors. In the present study. we were interested in determining if tumours in male mice with a comparable growth rate to that in females, also had a morphology similar to that in females. SC115 tumours were examined using histochemical and immunohistochemical techniques. Tumours in male mice were easily distinguishable from tumours in female mice regardless of growth rate. Tumours maintained in female mice contained osteoidlike regions which stained positive for sialic acid and sulphate moieties. No such regions were observed in any of the tumours from male mice. In addition, although all tumours contained MSA (muscle specific actin) -positive and S100 protein-positive cells, these regions were more extensive in the tumours of female mice. This study suggests that tumour growth rate and morphology are independently regulated by the host environment
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    S-100 protein in human lung neuroendocrine neoplasms. Immunohistochemical study of 14 cases and review of the literature
    (Murcia : F. Hernández, 1987) Barbareschi, M.; Mauri, M.F.; Muscara, M.; Lo Re, V.
    A group of lung neuroendocrine (NE) neoplasms are investigated in view of the possible presence of S-100 protein immunoreactivity in their cells. The selected tumours were classified according to Gould et al. (1983a) and Mosca et al. (1985). They comprise 5 carcinoids, 3 neuroendocrine carcinomas of the well-differentiated type, or peripheral carcinoids, 5 neuroendocrine carcinomas of the intermediate cell type, or intermediate-cell, poorly differentiated carcinomas, 3 neuroendocrine carcinomas of the microcytoma type, or small cell carcinomas-SCC and a nodal metastasis of microcytoma. All but 2 tumours were immunoreactive for neuron specific enolase (NSE). Few S-100 immunoreactive cells were detected in 4 out of 5 carcinoids, in 1 out of 3 peripheral carcinoids, in 4 out of 5 poorly differentiated carcinomas and in the 3 microcytomas examined. No S-100 positive cells were found in the SCC's nodal metastasis. The S-100 immunolabelled cells can be interpreted as dendritic reticulum cells migrating through the tumours. However, in one case of typical carcinoid, abundant S-100 positive cells were detected: their stellate morphology and their intimate relation with neoplastic cells suggest that they are part of the neoplasia as a sort of satellite cell.
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    Ultrastructural localization of S-1 00 protein in rat popliteal lymph nodes, and very slight proliferative activity of follicular dendritic cells
    (Murcia : F. Hernández, 1996) Sato, H.; Dobashi, Michio
    The purposes of this study were to examine the tissue distribution of S-100 protein in rat lymph nodes at the ultrastructural level with respect to the relationship between follicular dendritic cells (FDCs) and antigen transporting cells (ATCs), and to determine whether FDCs increase after secondary stimulation with sheep red blood cells (SRBCs). We examined the ultrastructural localization of S-100 protein in rat popliteal lymph nodes, and the density of S-100 proteinpositive FDCs in lymphoid follicles, after secondary stimulation with SRBCs, on paraffin wax sections. We found S-100 protein expression in FDCs in al1 regions of lymphoid follicles, although FDCs in the central portion of lymphoid follicles showed stronger reactions than FDCs in the periphery. S-100 protein recognized ATCs weakly. At the border between the subsinus layer and the lymphoid follicles, ATCs were very close to FDCs. There were only two mitotic S-100 protein-positive cells in the lymphoid follicles of al1 specimens. The density of S- 100 protein-positive FDCs in the lymphoid follicles in secondary stimulated rats was significantly lower than in primary stimulated rats. We suggest that S-100 protein expression reflects FDC development and supports a close relationship between FDCs and ATCs. FDCs may have only very slight proliferative activity, though the FDC density in the lymphoid follicles decreased after secondary stimulation