Publication: Ultrastructural localization of S-1 00 protein in rat popliteal lymph nodes, and very slight proliferative activity of follicular dendritic cells
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Date
1996
Authors
Sato, H. ; Dobashi, Michio
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The purposes of this study were to examine
the tissue distribution of S-100 protein in rat lymph
nodes at the ultrastructural level with respect to the
relationship between follicular dendritic cells (FDCs)
and antigen transporting cells (ATCs), and to determine
whether FDCs increase after secondary stimulation with
sheep red blood cells (SRBCs). We examined the
ultrastructural localization of S-100 protein in rat
popliteal lymph nodes, and the density of S-100 proteinpositive
FDCs in lymphoid follicles, after secondary
stimulation with SRBCs, on paraffin wax sections. We
found S-100 protein expression in FDCs in al1 regions of
lymphoid follicles, although FDCs in the central portion
of lymphoid follicles showed stronger reactions than
FDCs in the periphery. S-100 protein recognized ATCs
weakly. At the border between the subsinus layer and the
lymphoid follicles, ATCs were very close to FDCs.
There were only two mitotic S-100 protein-positive cells
in the lymphoid follicles of al1 specimens. The density of
S- 100 protein-positive FDCs in the lymphoid follicles in
secondary stimulated rats was significantly lower than in
primary stimulated rats. We suggest that S-100 protein
expression reflects FDC development and supports a
close relationship between FDCs and ATCs. FDCs may
have only very slight proliferative activity, though the
FDC density in the lymphoid follicles decreased after
secondary stimulation
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