Publication: A histological study of the Shionogi adenocarcinoma 115 grown in male and female mice
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Date
1990
Authors
Rowse, Guerry J. ; Rowan, Rosemary E. ; Worth, Ann J. ; Reid, Phil E. ; Weinberg, Joanne ; Emerman, Joanne T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
We have previously demonstrated that
growth rate and morphology differ between androgenresponsive
Shionogi mouse mammary tumours maintained
in male and female mice. Furthermore, we can modulate
the growth rate of these tumours in male mice by
exposing the mice to psychosocial stressors. In the
present study. we were interested in determining if
tumours in male mice with a comparable growth rate to
that in females, also had a morphology similar to that
in females. SC115 tumours were examined using
histochemical and immunohistochemical techniques.
Tumours in male mice were easily distinguishable from
tumours in female mice regardless of growth rate.
Tumours maintained in female mice contained osteoidlike
regions which stained positive for sialic acid and
sulphate moieties. No such regions were observed in any
of the tumours from male mice. In addition, although all
tumours contained MSA (muscle specific actin) -positive
and S100 protein-positive cells, these regions were more
extensive in the tumours of female mice. This study
suggests that tumour growth rate and morphology are
independently regulated by the host environment
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