Browsing by Subject "Injury"
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- PublicationOpen AccessActivin: A novel player in tissue repair processes(Murcia : F. Hernández, 1999) Hubner, G.; Alzheimer, C.; Werner, S.Recent studies have demonstrated a strong expression of activin in repair processes of various tissues and organs, including the skin, the lung, the intestine, the cardiovascular system, and even the brain. Although little is as yet known about the function of activin in tissue repair, first results suggest a role of activin in epithelia1 differentiation, fibroblast proliferation and expression of matrix molecules by these cells, and also in neuroprotection. Whereas a transient overexpression of activin after tissue injury might be beneficial for the repair process, sustained expression of activin could lead to fibrotic processes. Therefore, the modulation of the availability or biological activity of activin could be of particular importance for the treatment of impaired tissue repair on the one hand and tissue fibrosis on the other hand.
- PublicationOpen AccessCatecholamine-induced heart injury in mice: differential effects of isoproterenol and phenylephrine(Murcia : F. Hernández, 2010) Navarro Sobrino, Míriam; Lorita, Jordi; Soley, María; Ramírez, Ignasi-
- PublicationOpen AccessChaperone-mediated autophagy sustains pericyte stemness necessary for brain tissue homeostasis(Elsevier, 2025-04-24) Salinas, María Dolores; Martínez, Carlos M.; Roca, Francisco J.; García-Bernal, David; Martínez-Morga, Marta; Rodríguez-Madoz, Juan R.; Prósper, Felipe; Zapata, Agustín G.; Moraleda, José María; Martínez, Salvador; Valdor, Rut; Bioquímica y Biología Molecular B e InmunologíaIntroduction: Pericytes (PCs) are mural cells exhibiting some mesenchymal stem cell (MSC) properties and contribute to tissue regeneration after injury. We have previously shown that glioblastoma cancer cells induce in PCs, a pathogenic upregulation of chaperone-mediated autophagy (CMA) which modulates immune functions and MSC-like properties to support tumor growth. Objectives: The aim of the study was to interrogate the role of CMA-regulated MSC properties in PCs in the context of tissue repair during inflammation triggered by a demyelinating injury. Methods: Studies of RNA-seq were done PCs with (WT) and without (LAMP-2A KO) CMA. Cell characterization related to stemness, lineage and morphology was done in WT and KO PCs. Secretome analysis and cell differentiation assay using the supernatants from CMA-efficient and deficient PCs cultures was done in mesenchymal cells. Inflammatory response of brain cells was assessed with WT and KO PCs secretome. To corroborate in vitro results, CMA modulation in response to inflammation in PCs and tissue repair markers were measured in the lesion areas of a demyelination mouse model and correlated with the tissue reparation after intravenous PC administration. An inflammatory mediator was used to study effects on PC-CMA activity. Results We found that inflammatory mediators such as IFNγ downregulate CMA in PCs, suppressing PC stemness and promoting a pro-inflammatory secretome. Restoration of PC CMA activity during inflammation maintains PC MSC properties and induces an MSC-like proteome which decreases inflammation and promotes tissue repair. We identified secreted proteins involved in regenerative and protective processes, and therefore, necessary to restore brain tissue homeostasis after inflammation induced by a demyelinating injury. Conclusion: we show that manipulation of CMA activity in host PCs could be a useful therapeutical approach in the context of brain inflammation, which might be extended to other diseases where the pericyte has a key role in response to inflammation.
PublicationOpen AccessEffect of 12 weeks of modified FIFA 11+ training on functional factors of male beach soccer players: A Randomized Controlled Trial study(Universidad de Murcia. Servicio de publicaciones, 2024) Sharifatpour, Reza; Abbasi, Hamid; Hossein Alizadeh, Mohammad; Abedinzadeh, Saeed; Machado, SergioThe purpose of the study was to investigate the effect of modified FIFA 11+ training on functional factors of beach soccer players. The study is an RCT. Forty subjects divided to two control and exercise groups. functional factors was collected by the Bosco jump test on the force plate. repeated measures ANOVA was used to compare, between groups and the intervention group, as well as the effect of intervention. Statistical analyses were performed using SPSS at the significant level of 0.05. The result showed that Bosco index (F1,38= 42.85, p <0.001), power index (F1,38= 12.33, p = 0.001) and equilibrium index (F1,38 = 127.11, p = 0.001) were increased after intervention. The time × group interaction for the Bosco-index was significant. The modified FIFA 11+ which performed in the sand had an effect on functional factors. these exercises are recommended for beach soccer players to improve their performance- PublicationOpen AccessEpidemiología de las lesiones en el parkour y revisión de la literatura(Murcia: Servicio de publicaciones de la Universidad de Murcia, 2020) Giner Gran, Miguel ÁngelEl parkour es una actividad física cada vez más popular que continúa atrayendo practicantes. El objetivo de esta investigación es analizar la prevalencia de lesiones en el parkour así como la naturaleza, zona anatómica, procedimiento requerido, lugar dónde sucedió y movimiento de parkour. Se analizó a los practicantes de la Comunidad de Madrid, un total de 161 sujetos con una experiencia mínima de 12 meses y una prác-tica regular de al menos 1 vez por semana, empleando un cuestionario ad hoc. Los resultados muestran una prevalencia de lesión del 70,2%, siendo más frecuentes: esguinces (22,3%) y contusiones (21,1%), extremidad inferior (69,9%) y superior (24,7%), no precisaron pruebas médicas ni cirugía (68,6%), parque/plaza (60,9%) y calle (28%), salto de precisión (18,8%) y salto de longitud (11,1%). Por consiguiente se confirma que el parkour es susceptible de sufrir lesiones, en su mayoría esguinces, en la extremidad inferior y no resultan graves.
- PublicationOpen AccessLow range of shoulders horizontal abduction predisposes for shoulder pain in competitive young swimmers(Frontiers Media, 2019-03-06) Cejudo, Antonio; Sánchez Castillo, Sheila; Sainz de Baranda, Pilar; Carlos Gámez, Juan; Santonja Medina, Fernando; Cirugía, Pediatría y Obstetricia y GinecologíaThe prevalence of shoulder pain (SP) among competitive swimmers is high, and may profoundly restrict their ability to compete. This prospective cohort study investigated the association between 3 blocks of performance factors (anthropometric characteristics, sport experience and training regimen) and the presence of SP. The aims of the present study were: (a): to determine the profile of shoulder flexibility in young swimmers, (b) to analyze whether a restricted range of movement (ROM) could be a predictor of subsequent SP in young swimmers. 24 competitive young swimmers were measured in the 2016 pre-season. Measures of passive maximal shoulder extension (SE), flexion (SF), horizontal abduction (SHAB), abduction (SAB), horizontal adduction (SHADD), external (SER) and internal (SIR) rotation ROMs were taken. SP was prospectively monitored during the subsequent season using questionnaires. The data was analyzed via a binary logistic regression and ROC curves were calculated. At the follow-up, 16 swimmers (50%) had developed unilateral SP. Only reduced SHAB ROM was associated with SP [SP group 36.6◦ vs. pain-free group 41.5◦ ; p = 0.005, d = −0.96 (moderate effect sizes)]. Using the coordinates of the curves, the angle of SHAB ROM that most accurately identified individuals at risk of developing SP was determined to be 39◦ (sensibility 0.656 and 0.375 specificity). Swimmers with limited ROM (≤39◦ ) have 3.6 times higher risk of developing SP than swimmers with normal ROM (>39◦ ). This study clearly shows that low range of SHAB is a risk factor for developing SP in competitive young swimmers. In the studied data, a SHAB range of 39◦ was found to be the most appropriate cut-off point for prognostic screening.
- PublicationOpen AccessPensamiento catastrofista y evolución del estado de ánimo en futbolistas lesionados(Federación Española de Docentes de Educación Física, 2023-01-02) Candel Carrillo, María José; Mompeán Rey, Raquel; Olmedilla Zafra, Aurelio; Giménez Egido, José María; Personalidad, Evaluación y Tratamiento PsicológicosNumerosas investigaciones anteriores se han ocupado de estudiar los efectos en variables psicológicas que el pensamiento catastrofista consecuente a una lesión deportiva produce en la salud mental del individuo. Sin embargo, son menos las que han hecho hincapié en el impacto en el estado de ánimo del deportista desde una perspectiva longitudinal. En este estudio se empleó una muestra de 22 futbolistas varones jóvenes lesionados con el objetivo de observar la evolución temporal de la relación entre el pensamiento catastrofista y el estado de ánimo. El estudio se llevó a cabo en la Policlínica de la Federación de Futbol de la Región de Murcia (FFRM), España. Se obtuvo información sociodemográfica y sobre la lesión actual y la historia de lesiones del deportista, además de la información relativa a las variables psicológicas, pensamiento catastrofista y estado de ánimo. Se encuentra una relación tanto positiva como negativa, donde a mayor catastrofismo (Rumiación, Desesperación y Magnificación) mayor es el estado de ánimo negativo (Tensión, Depresión, Cólera y Fatiga) y menor es el estado de ánimo positivo (Vigor). Conforme aumenta el tiempo posterior a la lesión, el perfil psicológico mejora, disminuyendo de forma lineal los factores negativos y aumentando el factor positivo. Estos hallazgos pueden ser de importancia de cara a la planificación y a la aplicación de programas de rehabilitación para futbolistas lesionados.
- PublicationOpen AccessPsychometric analysis and effectiveness of the psychological readiness of injured athlete to return to sport (PRIA‐RS) questionnaire on injured soccer players(MDPI, 2020-02-27) Gómez Piqueras, Pedro; Ardern, Clare; Prieto Ayuso, Alejandro; Robles Palazón, Francisco Javier; Cejudo, Antonio; Sainz de Baranda, Pilar; Olmedilla Zafra, Aurelio; Personalidad, Evaluación y Tratamiento PsicológicosThe decision‐making process about when an athlete may safely return to training and competition after an injury is a difficult decision. Safe return to training and competition is characterised by physical and psychological readiness to return to the sport. The objectives of this study are (1) to assess the measurement properties of the Psychological Readiness of Injured Athlete to Return to Sport questionnaire (PRIA‐RS), and (2) to analyse the effectiveness which the PRIA‐RS questionnaire possesses when applied during four consecutive seasons on professional soccer players. One hundred and nine male soccer players from the Albacete Soccer Club (Spain) were involved during four consecutive seasons for the current study: 2012–2013, 2013–2014, 2014– 2015 and 2015–2016. Psychometric analysis (validity, reliability, internal consistency and effectiveness) and external psychometric analysis (evaluating measures of patient‐reported outcomes (EMPRO)) were confirmed and supported. The main results of the study reveal that the psychometric properties of this questionnaire are optimum for their application in a professional sports context.
- PublicationOpen AccessSagittal spinal morphotype assessment in 8 to 15 years old Inline Hockey players(PeerJ Inc, 2020-01-02) Sainz de Baranda Andújar, Pilar; Cejudo, Antonio; Moreno Alcaraz, Victor Jesús; Martínez Romero, María Teresa; Aparicio Sarmiento, Alba; Santonja Medina, Fernando; Cirugía, Pediatría y Obstetricia y GinecologíaBackground: Physiological sagittal spinal curvatures play an important role in health and performance in sports. For that reason, several scientific studies have assessed spinal morphology in young athletes. However, to our knowledge, no study has assessed the implications of Inline Hockey (IH) practice on sagittal integrative spinal morphotype in adolescent players. Objectives: The aims of the present study were to describe habitual sagittal spinal posture in young federated IH players and its relationship with training load and to determine the sagittal integrative spinal morphotype in these players. Methods: An observational analysis was developed to describe the sagittal spinal morphotype in young federated IH players. A total of 74 IH players from the Technification Plan organized by the Skating Federation of the Valencian Community (aged from 8 to 15 years) participated in the study. Thoracic and lumbar curvatures of the spine were measured in a relaxed standing position (SP), in a slump sitting position (SSP) and in maximum flexion of the trunk (MFT) to determine the “Sagittal Integrative Morphotype” of all players. An unilevel inclinometer was used to quantify the sagittal spinal curvatures. The Hip Joint Angle test was used to quantify the Lumbo-Horizontal angle in flexion (L-H fx) of all participants with a goniometer. Results: When thoracic curvature was analyzed according to normality references, it was found that 64.9% of IH players had thoracic hyperkyphosis in a SSP, while 60.8% and 74.3% of players were classified as normal in a SP and in MFT, respectively. As for the lumbar curve, 89.2% in a SP and 55.4% in MFT were normal, whereas 68.9% of IH players presented lumbar hyperkyphosis in a SSP. Regarding the “Sagittal Integrative Morphotype,” only 17.6% of players were classified as “Normal” in the three measured positions for the thoracic curve, while 37.8% had “Thoracic Hyperkyphosis” and 41.8% presented “Functional Thoracic Hyperkyphosis.” As for the “Sagittal Integrative Lumbar Morphotype,” only 23% of athletes had a normal curve in the three positions, whereas 66.2% presented “Functional Lumbar Hyperkyphosis.” When the L-H fx was evaluated, the results showed that only 16.2% of the athletes were classified as normal. Conclusions: Federative IH practice seems to cause specific adaptations in spinal sagittal morphotype. Taking into account the “Sagittal Integrative Morphotype” only 17.6% IH players presented “Normal Morphotype” with a normal thoracic kyphosis in the three measured positions, while only 23% IH players presented “Normal Morphotype” with a normal lumbar curvature in the three assessed positions. Furthermore, only 16.2% of IH players showed normal pelvic tilt. Exercise programs to prevent or rehabilitate these imbalances in young IH players are needed.
- PublicationOpen AccessTraducción y adaptación al inglés de un cuestionario para determinar la predisposición psicológica del futbolista lesionado(RPD-online, 2020-09-30) Gómez Piqueras, Pedro; Ruíz Barquín, Roberto; Olmedilla Zafra, Aurelio; Personalidad, Evaluación y Tratamiento PsicológicosDiferentes estudios han mostrado que una mala predisposición psicológica del deportista lesionado podría dificultar su retorno a los entrenamientos. El objetivo de este trabajo consistió en traducir y adaptar del castellano al inglés el cuestionario de predisposición psicológica para deportistas lesionados. Se utilizó una metodología de traducción-retrotraducción con traductores nativos y expertos en el campo de la recuperación de lesiones. Los traductores encontraron una equivalencia conceptual alta entre ambas versiones, así como un nivel de dificultad para su traducción bajo. El cuestionario PRIA-RS se presenta como una versión válida conceptual y contextualmente cuyo uso a nivel internacional, gracias a esta nueva versión en inglés, podría verse incrementado. -----------------------
- PublicationOpen AccessValoración funcional en futbolistas y su utilidad en la recuperación tras una lesión(Murcia: Servicio de publicaciones de la Universidad de Murcia, 2020) Gómez Piqueras, Pedro; González Villora, Sixto; Sánchez González, Marta; Sainz de Baranda Andújar, PilarObjetivo: El objetivo del presente estudio consistió en estable-cer valores de referencia para futbolistas profesionales en una serie de test funcionales seleccionados previamente. Método: Durante dos temporadas (2012/13 y 2013/14) y en tres momentos distintos de las mismas, 42 futbo-listas profesionales fueron evaluados funcionalmente mediante las siguien-tes pruebas: CMJ (salto bipodal), 5 m Shuttle Run Sprint Test (velocidad/agilidad), Test de Barrow (agilidad), Y Balance Test (control postural), Sin-gle Hop Test y Triple Hop Test (salto unipodal).Resultados: Los valores medios obtenidos fueron: CMJ (40.25±4.13cm), 5 m Shuttle Run Sprint Test (10.89±0.38 segundos), Test de Barrow (7.46±0.27 segundos), Y Balance asimetría derecha (4.63±2.16%), Y Balan-ce asimetría izquierda (3.91±2.25%), Single Hop Test derecha (2.06±0.11 metros), Single Hop Test izquierda (2.07±0.12 metros), Triple Hop Test derecha (6.87±0.29 metros) y Triple Hop Test izquierda (6.83±0.31).Conclusión: Este trabajo contribuye aportando valores de referencia que puedan ser utilizados para cuantificar el grado de recuperación funcional durante la recuperación de un futbolista profesional lesionado.