Publication: Activin: A novel player in tissue repair processes
Authors
Hubner, G. ; Alzheimer, C. ; Werner, S.
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Publisher
Murcia : F. Hernández
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Description
Abstract
Recent studies have demonstrated a strong
expression of activin in repair processes of various
tissues and organs, including the skin, the lung, the
intestine, the cardiovascular system, and even the brain.
Although little is as yet known about the function of
activin in tissue repair, first results suggest a role of
activin in epithelia1 differentiation, fibroblast
proliferation and expression of matrix molecules by
these cells, and also in neuroprotection. Whereas a
transient overexpression of activin after tissue injury
might be beneficial for the repair process, sustained
expression of activin could lead to fibrotic processes.
Therefore, the modulation of the availability or
biological activity of activin could be of particular
importance for the treatment of impaired tissue repair on
the one hand and tissue fibrosis on the other hand.
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