(Universidad de Murcia. Departamento de Biología Celular e Histología, 2017) Chiricozzi, A.; Romanelli, M.; Panduri, S.; Donetti, E.; Prignano, F.
Psoriasis is a chronic skin disease
characterized by the activation of various T cell subsets
secreting IFNγ, IL-17, and IL-22, dendritic cells
producing TNFα and IFNα, and other immune cells
including neutrophils and mast cells. Keratinocytes
respond to different cytokine signals orchestrating innate
and adaptive immune responses. In vitro studies sought
to clarify the cytokine effects on keratinocytes in order
to evaluate the centrality of these mediators in psoriasis
pathogenesis. The aim of this review is to highlight the
relevance of this peculiar in vitro approach in
investigating cytokine effects on skin or multilayered
epidermis. Particularly, we reported keynfinding