Publication:
Relevance of in vitro 3-D skin models in dissecting cytokine contribution to psoriasis pathogenesis

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Chiricozzi-32-893-898-2017.pdf(114.91 KB)
Date
2017
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Authors
Chiricozzi, A. ; Romanelli, M. ; Panduri, S. ; Donetti, E. ; Prignano, F.
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
10.14670/HH-11-877
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info:eu-repo/semantics/article
Description
Abstract
Psoriasis is a chronic skin disease characterized by the activation of various T cell subsets secreting IFNγ, IL-17, and IL-22, dendritic cells producing TNFα and IFNα, and other immune cells including neutrophils and mast cells. Keratinocytes respond to different cytokine signals orchestrating innate and adaptive immune responses. In vitro studies sought to clarify the cytokine effects on keratinocytes in order to evaluate the centrality of these mediators in psoriasis pathogenesis. The aim of this review is to highlight the relevance of this peculiar in vitro approach in investigating cytokine effects on skin or multilayered epidermis. Particularly, we reported keynfinding
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Psoriasis , RHE , Skin equivalent , IL-17 , IL22 , TNFα , IFNγ
Citation
Histology and Histopathology, Vol.32, nº9, (2017)
URI
http://hdl.handle.net/10201/117514
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Histology and histopathology Vol.32, nº9 (2017)
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