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Título: | Hepatocyte growth factor/scatter factor and prostate cancer: a review |
Fecha de publicación: | 2005 |
Editorial: | Murcia : F. Hernández |
ISSN: | 0213-3911 |
Materias relacionadas: | CDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncología::616.6 - Patología del sistema genitourinario |
Palabras clave: | Hepatocyte growth factor Prostate cancer |
Resumen: | Men who die from prostate cancer do so from uncontrolled metastatic disease. A better understanding of the mechanisms involved in the progression and metastasis of prostate cancer may lead to novel therapeutic approaches to prevent its natural progression. Hepatocyte Growth Factor / Scatter factor (HGF/SF) has been demonstrated to elicit a number of key functions in numerous tissues that are important in the progression, invasion and metastasis of cancer. Studies have demonstrated that the activity of HGF/SF and its receptor c-Met are linked to disease progression in numerous cancers. However, research into these functions, which include activities as a mitogen, a motogen and an anti-apoptotic and angiogenic factor in prostate cancer are limited. This article reviews the published evidence of the roles HGF/SF plays in prostate cancer progression and highlights the clinical and therapeutic potential of research into this pleiomorphic cytokine. |
Autor/es principal/es: | Hurle, R.A. Davies, Graham Parr, C. Mason, M.D. Jenkins, S.A. Kynaston, H.G. Jiang, W.G. |
Forma parte de: | Histology and histopathology |
URI: | http://hdl.handle.net/10201/22534 |
Tipo de documento: | info:eu-repo/semantics/article |
Número páginas / Extensión: | 11 |
Derechos: | info:eu-repo/semantics/openAccess |
Aparece en las colecciones: | Vol.20, nº 4 (2005) |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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Hepatocyte growth factor scatter.pdf | 800,71 kB | Adobe PDF | Visualizar/Abrir |
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