High histamine expression by early-stage squamous cell carcinoma of the tongue is associated with a poor prognosis

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dc.contributor.authorHirotsugu Noguchi
dc.contributor.authorHiroaki Sato
dc.contributor.authorShohei Shimajiri
dc.contributor.authorToshiyuki Nakayama
dc.contributor.authorSatoshi Kimura
dc.contributor.departmentBiología Celular e Histología
dc.date.accessioned2025-12-17T10:09:47Z
dc.date.available2025-12-17T10:09:47Z
dc.date.issued2026
dc.description.abstractBackground. Although not widely known, several types of cancers express histamine. Squamous cell carcinoma (SCC) of the tongue is one such cancer, and histamine expression is associated with the tumor microenvironment. Our aim was to examine whether histamine expression is a useful prognostic factor for tongue SCC. Methods. Histamine cannot be accurately measured directly because it is rapidly degraded after secretion. Therefore, L-histidine decarboxylase (HDC), an enzyme that synthesizes histamine in a single step, was used to estimate histamine secretion. In a retrospective study, tongue SCC samples from patients were immunohisto-chemically stained for HDC; the staining intensity was semi-quantified and evaluated relative to indices used in histopathological diagnosis. Results. High expression of HDC was associated with the worst tumor invasion and tumor budding. Overall survival curves revealed that patients with tongue SCC showing high HDC expression had a poor prognosis. Conclusion. The expression of histamine may be a prognostic indicator for tongue SCC.
dc.formatapplication/pdf
dc.format.extent7
dc.identifier.doihttps://doi.org/10.14670/HH-18-938
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/180909
dc.languageeng
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologia
dc.relationSin financiacion externa a la Universidad
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectHistamine
dc.subjectSCC of the tongue
dc.subjectTumor budding
dc.subjectWorst pattern of invasion
dc.subjectHDC
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleHigh histamine expression by early-stage squamous cell carcinoma of the tongue is associated with a poor prognosis
dc.typeinfo:eu-repo/semantics/article
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Histology and histopathology, Vol.41, Nº1, (2026)