High histamine expression by early-stage squamous cell carcinoma of the tongue is associated with a poor prognosis

Thumbnail Image
Files
Kimura-41-61-67-2026.pdf(8.42 MB)
Date
2026
Authors
Hirotsugu Noguchi
Hiroaki Sato
Shohei Shimajiri
Toshiyuki Nakayama
Satoshi Kimura
Journal Title
Journal ISSN
Volume Title
Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
Abstract
Background. Although not widely known, several types of cancers express histamine. Squamous cell carcinoma (SCC) of the tongue is one such cancer, and histamine expression is associated with the tumor microenvironment. Our aim was to examine whether histamine expression is a useful prognostic factor for tongue SCC. Methods. Histamine cannot be accurately measured directly because it is rapidly degraded after secretion. Therefore, L-histidine decarboxylase (HDC), an enzyme that synthesizes histamine in a single step, was used to estimate histamine secretion. In a retrospective study, tongue SCC samples from patients were immunohisto-chemically stained for HDC; the staining intensity was semi-quantified and evaluated relative to indices used in histopathological diagnosis. Results. High expression of HDC was associated with the worst tumor invasion and tumor budding. Overall survival curves revealed that patients with tongue SCC showing high HDC expression had a poor prognosis. Conclusion. The expression of histamine may be a prognostic indicator for tongue SCC.
Description
Keywords
Histamine , SCC of the tongue , Tumor budding , Worst pattern of invasion , HDC
Citation
URI
http://hdl.handle.net/10201/180909
item.page.embargo
Collections
Histology and histopathology, Vol.41, Nº1, (2026)
Ir a Estadísticas