Publication: Smoothelin and WT-1 expression in glomus tumors and glomuvenous malformations
Authors
Aneiros Fernandez, Jose ; Retamero, Juan Antonio ; Husein ElAhmed, Husein ; Carriel, Víctor ; Ruiz Villaverde, Ricardo ; O’Valle, Francisco ; Aneiros Cachaza, Jose
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
DOI: 10.14670/HH-11-782
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info:eu-repo/semantics/article
Description
Abstract
Background: Smoothelin is a specific marker
for smooth muscle cells with contractile capacity which
has not been widely studied in glomus lesions. In the
same way, the expression for Wilms tumor 1 (WT1) has
only been studied occasionally in the endothelial cells of
glomovenous malformations and in the glomus cells of
glomus tumours. Objective: We studied the significance
of immunohistochemical expression of smoothelin and
WT1 in 25 glomus lesions. Methods: We assessed 9
cases of solid glomus tumors (SGT), 8 cases of glomus
tumors with vascular ectasia (VEGT), 2 cases of
glomangiomyomas (GMM) and 6 cases of glomuvenous
malformation (GM). Immunohistochemistry was
performed, evaluating the expression of WT1,
smoothelin, smooth muscle actin (SMA), smooth muscle
myosin (SMM), h-caldesmon and desmin. Results:
Glomic cells showed cytoplasmic positivity for
smoothelin, and WT1 expression was present in all
studied cases. SGT showed WT1 positivity in all
endothelia. However, in regarding VEGT and GMM,
WT1 endothelial expression was positive in some areas,
but not in others. GM did not show endothelial cell
positivity for WT1. Conclusions: Smoothelin expression
in glomic cells indicates that they are contractile smooth
muscle cells, and thus its role in routine diagnosis should
be considered. The absence of WT1 expression in the
endothelium of the vascular structures of the GM is a
differential characteristic between SGT, VEGT and
GMM.
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Citation
Histology and Histopathology, Vol.32, nº2, (2017)
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