Publication: MITF is a critical regulator of the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in malignant melanoma
Authors
Ullrich, Nico ; Löffek, Stefanie ; Horn, Susanne ; Ennen, Marie ; Zhao, Fang ; Breitenbuecher, Frank ; Davidson, Irwin ; Singer, Bernhard B ; Schadendorf, Dirk ; Goding, Colin R ; Helfrich, Iris ; Sánchez del Campo Ferrer, Luis
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Publisher
Wiley
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DOI
https://doi.org/10.1111/pcmr.12414
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info:eu-repo/semantics/article
Description
© 2015 John Wiley & Sons A/S. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted version of a Published Work that appeared in final form in Pigment cell & melanoma research. To access the final edited and published work see https://doi.org/10.1111/pcmr.12414
Abstract
The multifunctional Ig-like carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is neo-expressed in the majority of malignant melanoma lesions. CEACAM1 acts as a driver of tumor cell invasion, and its expression correlates with poor patient prognosis. Despite its importance in melanoma progression, how CEACAM1 expression is regulated is largely unknown. Here, we show that CEACAM1 expression in melanoma cell lines and melanoma tissue strongly correlates with that of the microphthalmia-associated transcription factor (MITF), a key regulator of melanoma proliferation and invasiveness. MITF is revealed as a direct and positive regulator for CEACAM1 expression via binding to an M-box motif located in the CEACAM1 promoter. Taken together, our study provides novel insights into the regulation of CEACAM1 expression and suggests an MITF-CEACAM1 axis as a potential determinant of melanoma progression.
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Citation
Pigment cell & melanoma research, 2015, Vol. 28, N. 6, pp. 736-740
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Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/