Publication: Scanning electron and light microscopic observations on the healing process after sintered bone implantation in rats
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Date
1995
Authors
Matsuda, Mikio ; Kita, S. ; Takekawa, M. ; Ohtsubo, S. ; Tsuyama, K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The healing process after implantation of
sintered bone in the rat parietal bone was compared with
that of synthetic hydroxyapatite using both scanning
electron and light microscopy. The results showed that
the differences between the sintered natural bone and the
synthetic hydroxyapatite implantations were in the states
of bone union and the bioresorbability of the implanted
materials, even though both materials consist of the
same hydroxyapatite. In the sintered bone implantation,
the newly formed bone invaded into the material at 1 to
2 weeks after implantation. The sintered bone surface on
the dura mater side was completely covered by the new
bone at 5 weeks. It is noteworthy that bone resorbing
areas characterized by Howship's lacunae were observed
on the sintered bone surface at 2 weeks and the material
was replaced by new bone. Light microscopy, which
revealed the invasion and the development of the new
bone into the sintered bone, supported the scanning
electron microscopic observations. In the synthetic
hydroxyapatite, the new bone adhered closely to the
material just like the sintered bone implantation. The
new bone did not invade into the synthetic hydroxyapatite.
There was no evidence of the resorption of the
hydroxyapatite. This shows that the natural and the
biological structures of the sintered bone offer an
advantageous environment to fluid circulation and
ingrowth after implantation.
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