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Disposition of dietary polyphenols in breast cancer patients’ tumors, and their associated anticancer activity: the particular case of curcumin

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dc.contributor.authorÁvila-Gálvez, María Ángeles
dc.contributor.authorGonzález Sarrías, Antonio
dc.contributor.authorMartínez Díaz, Francisco
dc.contributor.authorAbellán, Beatriz
dc.contributor.authorMartínez-Torrano, Alejandro José
dc.contributor.authorFernández-López, Antonio José
dc.contributor.authorGiménez-Bastida, Juan Antonio
dc.contributor.authorEspín, Juan Carlos
dc.contributor.departmentOftalmología, Optometría, Otorrinolaringología y Anatomía Patológica
dc.date.accessioned2024-12-12T11:54:18Z
dc.date.available2024-12-12T11:54:18Z
dc.date.issued2021-05-10
dc.description© 2021 The Authors. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This document is the Published version of a Published Work that appeared in final form in Molecular Nutrition & Food Research. To access the final edited and published work see https://doi.org/10.1002/mnfr.202100163
dc.description.abstractScope: Some polyphenol-derived metabolites reach human breast cancer (BC) tissues at concentrations that induce cell senescence. However, this is unknown for isoflavones, curcuminoids, and lignans. Here, their metabolic profiling in normal (NT) and malignant (MT) mammary tissues of newly-diagnosed BC patients and the tissue-occurring metabolites’ anticancer activity are evaluated. Methods and results: Patients (n = 26) consumed 3 capsules/day (turmeric, red clover, and flaxseed extracts plus resveratrol; 296.4 mg phenolics/capsule) from biopsy-confirmed diagnosis to surgery (5 ± 2 days) or did not consume capsules (n = 13). NT and MT, blood, and urine are analyzed by UPLC-QTOF-MS using targeted metabolomics. Anticancer activity was tested in MCF-7 and MDA-MB-231 BC cells. Mainly phase-II metabolites were detected (108, 84, 49, and 47 in urine, plasma, NT, and MT, respectively). Total metabolite concentrations reached 10.7 ± 11.1 and 2.5 ± 2.4 µmol L–1 in NT and MT, respectively. Free curcumin, but not its glucuronide, was detected in the tissues (1.1 ± 1.8 and 0.2 ± 0.2 µmol L–1 in NT and MT, respectively). Breast tissue-occurring metabolites’ antiproliferation was mainly exerted in p53-wild-type MCF-7 cells by curcuminoids through cell cycle arrest, senescence, and apoptosis induction via p53/p21 induction, while isoflavone-derived metabolites exerted estrogenic-like activity. Conclusion: Curcuminoids could be coadjuvants that might help fight BC upon regular consumption.es
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dc.identifier.citationMol. Nutr. Food Res. 2021, 65, 2100163
dc.identifier.doihttps://doi.org/10.1002/mnfr.202100163
dc.identifier.issnPrint: 1613-4125
dc.identifier.issnElectronic: 1613-4133
dc.identifier.urihttp://hdl.handle.net/10201/147384
dc.languageenges
dc.publisherWiley. Wiley-VCH Verlag
dc.relationThis research was supported by the Projects 201770E081 from the Spanish National Research Council (CSIC, Spain) and by PID2019-103914RB-I00 from the Ministry of Science and Innovation (MICINN, Spain). J.A.G.-B. was supported by a Standard European Marie Curie Fellowship from the European Commission. This project received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement no. 838991.es
dc.relation.publisherversionhttps://onlinelibrary.wiley.com/doi/10.1002/mnfr.202100163
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.titleDisposition of dietary polyphenols in breast cancer patients’ tumors, and their associated anticancer activity: the particular case of curcumines
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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