Publication: AgNOR and breast cancer. A study by image analysis
Authors
Ronco, A. ; Larran, J. ; Lopez, A. ; Vilches, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The nucleolar organizer regions are used as a
new marker in proliferation cell. AgNOR are loops of
DNA actively transcribing to ribosomal RNA and they
are associated with nonhistone proteins with strong
argyrophile. In the present study we correlated the
relationships between number and size of AgNOR
measured by an automatic image analysis using CAS-
100, in eleven breast carcinomas in different clinical
stages and histological grades. We could identify the
AgNOR with silver stain; the relationship between the
numberlsize and histological gradelclinical stage shows
that in normal breast we find one or two AgNOR but this
number is larger when the carcinomas are less
differentiated. When studied, the size is larger in the
normal breast. We can make the same conclusions with
the carcinomas which are lymph-node +.
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