Publication: Influence of nicotine and caffeine on rat embryonic development
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Date
1988
Authors
Nash, J.E. ; Persaud, T.V.N.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The influence on embryonic development of
nicotine and caffeine at dose levels approximating
human consumption was investigated in Sprague-
Dawley rats. One group of animals received nicotine
administered subcutaneously by an Alzet mini-osmotic
pump from gestational day 6 through 12 (25 mg over 7
days; rate 149 pg/hr). Control animals received
physiological saline in a similar manner. A second group
received a single intravenous injection of caffeine (25 mg/
kg) on gestational day 6. Control animals were treated
with physiological saline. A further group received both
nicotine and caffeine on gestational day 6 as described
for the two previous groups. There were no significant
differences among any of the groups with respect to
maternal weight gain, litter size, embryolethality, fetal
weight, or crown-rump length. The offspring of nicotine
treated animals showed a significantly higher incidence
of hydrocephaly when compared to the controls, but in
the combined treatment group no malformed fetuses
were observed. Light microscopic examination of
maternal liver, kidney and placentas revealed changes in
the hepatic sinusoids, glomeruli and intervillous spaces
after nicotine and combined treatment. In addition, the
decidua basalis was poorly developed compared to the
controls. Chorionic villi and fetal kidney appeared
normal in al1 groups. A coteratogenic effect is not
evident from these findings.
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