Browsing by Subject "Caffeine"

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    Early embryonic development in the rat following in utero exposure to alcohol and caffeine
    (Murcia : F. Hernández, 1986) Ross, C.P.; Persaud, T.V.N.
    The influence of both alcohol and caffeine on early embryonic development was investigated in pregnant rats. Compared to the corresponding controls, a high incidence of resorptions and abnormal embryos was induced following treatment of the animals with alcohol (0.015 ml/g body weight, 12.5% v/v, ¡.p.) on gestational days 6 through 12 and with caffeine (25 mg/kg body weight, ¡.v.) on gestational day 10. In addition, embryonic growth was severely affected. Reduction of placental blood circulation and impairment of cellular proliferation may account for the observed deleterious effects on the embryo.
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    Influence of nicotine and caffeine on rat embryonic development
    (Murcia : F. Hernández, 1988) Nash, J.E.; Persaud, T.V.N.
    The influence on embryonic development of nicotine and caffeine at dose levels approximating human consumption was investigated in Sprague- Dawley rats. One group of animals received nicotine administered subcutaneously by an Alzet mini-osmotic pump from gestational day 6 through 12 (25 mg over 7 days; rate 149 pg/hr). Control animals received physiological saline in a similar manner. A second group received a single intravenous injection of caffeine (25 mg/ kg) on gestational day 6. Control animals were treated with physiological saline. A further group received both nicotine and caffeine on gestational day 6 as described for the two previous groups. There were no significant differences among any of the groups with respect to maternal weight gain, litter size, embryolethality, fetal weight, or crown-rump length. The offspring of nicotine treated animals showed a significantly higher incidence of hydrocephaly when compared to the controls, but in the combined treatment group no malformed fetuses were observed. Light microscopic examination of maternal liver, kidney and placentas revealed changes in the hepatic sinusoids, glomeruli and intervillous spaces after nicotine and combined treatment. In addition, the decidua basalis was poorly developed compared to the controls. Chorionic villi and fetal kidney appeared normal in al1 groups. A coteratogenic effect is not evident from these findings.