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Prognostic significance of tumour vascularisation on survival of patients with advanced ovarian carcinoma

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dc.contributor.authorLabiche, Alexandrees
dc.contributor.authorElie, Nicolases
dc.contributor.authorHerlin, Paulette
dc.contributor.authorDenoux, Yves
dc.contributor.authorCrouet, Hubert
dc.contributor.authorHeutte, Natacha
dc.contributor.authorJoly, Florence
dc.contributor.authorHéron, Jean-François
dc.contributor.authorGauduchon, Pascal
dc.contributor.authorHenry-Amar, Michel
dc.date.accessioned2013-09-24T11:34:37Z
dc.date.available2013-09-24T11:34:37Z
dc.date.issued2009
dc.description.abstractObjective. The prognostic significance of microvessel density in ovarian cancer is still a matter of debate. Classically, the degree of vascularisation is assessed in areas of high vascular density (hot spots), considered as regions of increased probability of metastasis. Since ovarian tumours have a particular progression and dissemination behaviour, vascularisation outside hot spots may also contribute to their evolution. Methods. In the present study, the degree of tumour vascularisation was estimated both in whole histogical sections and in hot spots, in 235 patients with ovarian carcinoma, using fully automatic image analysis methods. Six parameters were estimated: mean microvessel density (MVD) and mean microvessel surface fraction (MSP) on the whole section, mean and maximum values of MVD and MSP inside hot spots (MVDHS1, MSPHS1 and MVDHS2, MSPHS2). Relationships between vascular parameters and clinicopathologic features were analysed. Results. In stage III-IV patients multivariate analysis showed that stage IV disease (hazards ratio (HR)=1.72, p=0.001), post-surgical residual disease 1cm (HR=2.86, p<0.001), upper MVD tercile (HR=1.45, p<0.022) and medial MVDHS1 tercile (HR=1.36, p=0.060) retained an independent prognostic value upon overall survival. Conclusion. Our results suggest that quantification of blood vessels, both on the whole histological section and in hot spots might be helpful in evaluating prognosis in advanced ovarian carcinomas.es
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/36015
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectOvarian canceres
dc.subjectPrognosises
dc.subject.other616.6 - Patología del sistema genitourinarioes
dc.titlePrognostic significance of tumour vascularisation on survival of patients with advanced ovarian carcinomaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.24, nº4 (2009)