Publication: Prognostic significance of tumour vascularisation on survival of patients with advanced ovarian carcinoma
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Date
2009
Authors
Labiche, Alexandre ; Elie, Nicolas ; Herlin, Paulette ; Denoux, Yves ; Crouet, Hubert ; Heutte, Natacha ; Joly, Florence ; Héron, Jean-François ; Gauduchon, Pascal ; Henry-Amar, Michel
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Objective. The prognostic significance of
microvessel density in ovarian cancer is still a matter of
debate. Classically, the degree of vascularisation is
assessed in areas of high vascular density (hot spots),
considered as regions of increased probability of
metastasis. Since ovarian tumours have a particular
progression and dissemination behaviour, vascularisation
outside hot spots may also contribute to their evolution.
Methods. In the present study, the degree of tumour
vascularisation was estimated both in whole histogical
sections and in hot spots, in 235 patients with ovarian
carcinoma, using fully automatic image analysis
methods. Six parameters were estimated: mean
microvessel density (MVD) and mean microvessel
surface fraction (MSP) on the whole section, mean and
maximum values of MVD and MSP inside hot spots
(MVDHS1, MSPHS1 and MVDHS2, MSPHS2).
Relationships between vascular parameters and
clinicopathologic features were analysed. Results. In
stage III-IV patients multivariate analysis showed that
stage IV disease (hazards ratio (HR)=1.72, p=0.001),
post-surgical residual disease 1cm (HR=2.86, p<0.001), upper MVD tercile (HR=1.45, p<0.022) and medial
MVDHS1 tercile (HR=1.36, p=0.060) retained an
independent prognostic value upon overall survival.
Conclusion. Our results suggest that quantification of
blood vessels, both on the whole histological section and
in hot spots might be helpful in evaluating prognosis in
advanced ovarian carcinomas.
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