Impact of Genetic and Environmental Factors on Peripheral Refraction

Pusti, D.; Benito, A.; Madrid-Valero, J.J.; Ordoñana, J.R.; Artal, P.

Publication:
Impact of Genetic and Environmental Factors on Peripheral Refraction

dc.contributor.author	Pusti, D.
dc.contributor.author	Benito, A.
dc.contributor.author	Madrid-Valero, J.J.
dc.contributor.author	Ordoñana, J.R.
dc.contributor.author	Artal, P.
dc.contributor.department	Física
dc.date.accessioned	2025-01-15T08:52:38Z
dc.date.available	2025-01-15T08:52:38Z
dc.date.issued	2024-10-23
dc.description	© 2024 The authors This document is the published version of a published work that appeared in final form in Translational Vision Science & Technology (TVST) This document is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0 To access the final edited and published work see: https://doi.org/10.1167/tvst.13.10.33
dc.description.abstract	Investigate genetic and environmental influences on refractive errors in monozygotic (MZ) and dizygotic (DZ) twin pairs. We assessed foveal and peripheral refractions in 54 MZ and 46 DZ twins, capturing three scans across the retina. The study focused on spherical equivalent (M) at the fovea (MLOS) and changes in midperipheral (δMmid-periphery), and peripheral (δMperiphery) defocus, along with nasal-temporal asymmetry (root mean squared error [RMSEASY]) and image shell contour (RMSEAVG). Genetic and environmental contributions were analyzed using structural equation models. No significant differences were observed between MZ and DZ twins for the examined variables. Intraclass correlations (ICC) indicated an important difference in genetic influence between MLOS, with the MZ twin pairs showing a higher correlation (0.83) than DZ (0.69) pairs, and δMperiphery, because the ICC for the MZ doubled (0.87) that of the DZ (0.42) pairs. Heritability estimates from the ACE model confirmed the large difference on genetic factors' influence on the variance for MLOS (0.13) and δMperiphery (0.77) change in refractive error. RMSEASY and RMSEAVG metrics showed significant genetic impact, particularly pronounced in the peripheral measurements, revealing high genetic control. The study delineates a marked environmental impact on central refractive errors, whereas genetic factors had a more significant influence on peripheral refractive variance and retinal image traits. Findings of the ACE model highlight the intricate genetic and environmental interplay in refractive error development, with a notable genetic dominance in peripheral vision characteristics. This suggests potential genetic targets for interventions in myopia management and emphasizes the need for personalized approaches based on genetic predispositions. Understanding the impact of genetics and environment on peripheral refraction is essential for deepening our fundamental knowledge of myopia and guiding the development of advanced myopia control strategies.	es
dc.format	application/pdf	es
dc.format.extent	12	es
dc.identifier.doi	https://doi.org/10.1167/tvst.13.10.33
dc.identifier.eisbn	Transl Vis Sci Technol. 2024;13(10):33,
dc.identifier.issn	2164-2591
dc.identifier.uri	http://hdl.handle.net/10201/148462
dc.language	eng	es
dc.publisher	Association for Research in Vision and Ophthalmology	es
dc.relation	Supported by MyFUN, EU-ITN 675137, Agencia Estatal de Investigación, Spain (PID2019-105684RBI00/AEI/10.13039/501100011033). MyFUN receives funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 675137	es
dc.relation.publisherversion	https://tvst.arvojournals.org/article.aspx?articleid=2802165
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Peripheral refraction	es
dc.subject	Myopia
dc.subject	Behavioral genetics
dc.subject	Twins
dc.title	Impact of Genetic and Environmental Factors on Peripheral Refraction	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es