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Cape Town solution in prolonged myocardial preservation: structural and ultrastructural study

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dc.contributor.authorGarcía Poblete, E.
dc.contributor.authorAlvárez, L.
dc.contributor.authorFernández, H.
dc.contributor.authorEscudero, C.
dc.contributor.authorTorralba, A.
dc.date.accessioned2020-05-21T16:03:55Z
dc.date.available2020-05-21T16:03:55Z
dc.date.issued1998
dc.description.abstractThis study deals with myocardial preservation after 24 hours of continuous, hypothermic and oxygenated perfusion with Cape Town (CT) solution, focusing on the morphological changes produced by preservation and reperfusion, and their possible relationship to the composition of the solution and the immediate hemodynamic findings after orthotopic heart transplantation in dogs. After preservation, aside from mild or moderate mitochondrial changes, the most relevant lesions included edema and vasoconstriction. Reperfusion was followed by the development of areas of necrosis forming contraction bands and an increment in the mitochondrial damage ; the intercalated disks conserved their normal structure; edema became more prominent and was in variably accompanied by hemorrhage; vasoconstriction was very pronounced and was accompanied on occasion by evidence of capillary rupture; and inflammatory cells were observed in the interstitium. These results indicate that colloid must be added to Cape Town solution and that reperfusion probably requires selective approaches to deal with vasoconstriction and inflammation.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.citationHistology and histopathology, Vol.13, nº 1 (1998)
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/92454
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectProlonged myocardial preservationes
dc.subjectCape Town solutiones
dc.subjectContinuous perfusiones
dc.subjectReperfusion Injuryes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleCape Town solution in prolonged myocardial preservation: structural and ultrastructural studyes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.13, nº 1 (1998)