Publication: Cape Town solution in prolonged myocardial
preservation: structural and ultrastructural study
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Date
1998
Authors
García Poblete, E. ; Alvárez, L. ; Fernández, H. ; Escudero, C. ; Torralba, A.
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
This study deals with myocardial preservation after 24 hours of continuous, hypothermic and
oxygenated perfusion with Cape Town (CT) solution,
focusing on the morphological changes produced by
preservation and reperfusion, and their possible
relationship to the composition of the solution and the
immediate hemodynamic findings after orthotopic heart
transplantation in dogs. After preservation, aside from
mild or moderate mitochondrial changes, the most
relevant lesions included edema and vasoconstriction.
Reperfusion was followed by the development of areas
of necrosis forming contraction bands and an increment
in the mitochondrial damage ; the intercalated disks
conserved their normal structure; edema became more
prominent and was in variably accompanied by
hemorrhage; vasoconstriction was very pronounced and
was accompanied on occasion by evidence of capillary
rupture; and inflammatory cells were observed in the
interstitium. These results indicate that colloid must be
added to Cape Town solution and that reperfusion
probably requires selective approaches to deal with
vasoconstriction and inflammation.
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Citation
Histology and histopathology, Vol.13, nº 1 (1998)
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