Publication: Human Leukocyte Antigen-G (HLA-G)
as a marker for diagnosis, prognosis and
tumor immune escape in human malignancies
Authors
Yie, Shang-mian ; Hu, Zhenbo
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Publisher
Murcia: F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Human leukocyte antigen-G (HLA-G) is a
non-classical HLA-class Ib molecule with multiple
immunoregulatory properties. Its main functions in
physiological conditions are to abolish maternal immune
cell activity against fetus and to establish immune
tolerance at the maternal-fetal interface. In oncology,
HLA-G molecules are aberrantly expressed in a variety
of human neoplastic diseases and play an important role
in the escape of tumor cells from immune surveillance.
In the past few years, making use of HLA-G protein
expression in tissues and circulating levels in body fluids
as a tumor marker have been the focus of extensive
research in the diagnosis and prognosis of several human
malignancies. In addition, this molecule might be a
promising target for future immune therapeutic
approaches based on its immune tolerant functions and
its highly specific expression for malignant
transformation. In this review, we will summarize
available literature data as well as our own works on
HLA-G in cancer, and address some of the issues
concerning its application in human neoplasia.
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