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The participation of myofibroblasts in the capsular formation of human conventional and chromophobe renal cell carcinomas

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dc.contributor.authorShimasaki, N.es
dc.contributor.authorKuroda, Naotoes
dc.contributor.authorGuo, L.
dc.contributor.authorJin, Y.
dc.contributor.authorMiyazaki, E.
dc.contributor.authorHayashi, Yoshihiro
dc.contributor.authorToi, M.
dc.contributor.authorHiroi, Makoto
dc.contributor.authorEnzan, H.
dc.contributor.authorShuin, T.
dc.date.accessioned2011-06-30T11:59:47Z
dc.date.available2011-06-30T11:59:47Z
dc.date.issued2005
dc.description.abstractThe presence of myofibroblasts has been elucidated in neoplastic capsules of various organs. In the present article, we examine the presence of myofibroblasts in the capsule of renal cell carcinoma (RCC) and discuss the origin of the myofibroblasts. Nineteen renal tumors (conventional RCC, n=17; chromophobe RCC, n=2) with evident and totally surrounded fibrous capsule were selected. Abundant myofibroblasts were immunohistochemically observed in the capsule of the RCCs. These findings were confirmed by electron and immunoelectron microscopic studies of three conventional RCCs. Type III and I collagens were predominant in the outer and inner layers of the RCC capsule, respectively. The cytoplasm of the tubular epithelial cells in the tissue surrounding the neoplastic capsule stained positively for transforming growth factor (TGF)-ß1. In situ hybridization detected type I collagen mRNA in myofibroblasts of the capsule. Myofibroblasts may participate in the capsular formation of conventional and chromophobe RCCs through the collagen production.es
dc.formatapplication/pdfes
dc.format.extent7es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/22440
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCapsulees
dc.subjectMyofibroblastes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleThe participation of myofibroblasts in the capsular formation of human conventional and chromophobe renal cell carcinomases
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.20, nº 1 (2005)