Publication: The participation of myofibroblasts
in the capsular formation of human
conventional and chromophobe renal cell carcinomas
Authors
Shimasaki, N. ; Kuroda, Naoto ; Guo, L. ; Jin, Y. ; Miyazaki, E. ; Hayashi, Yoshihiro ; Toi, M. ; Hiroi, Makoto ; Enzan, H. ; Shuin, T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The presence of myofibroblasts has been
elucidated in neoplastic capsules of various organs. In
the present article, we examine the presence of
myofibroblasts in the capsule of renal cell carcinoma
(RCC) and discuss the origin of the myofibroblasts.
Nineteen renal tumors (conventional RCC, n=17;
chromophobe RCC, n=2) with evident and totally
surrounded fibrous capsule were selected. Abundant
myofibroblasts were immunohistochemically observed
in the capsule of the RCCs. These findings were
confirmed by electron and immunoelectron microscopic
studies of three conventional RCCs. Type III and I
collagens were predominant in the outer and inner layers
of the RCC capsule, respectively. The cytoplasm of the
tubular epithelial cells in the tissue surrounding the
neoplastic capsule stained positively for transforming
growth factor (TGF)-ß1. In situ hybridization detected
type I collagen mRNA in myofibroblasts of the capsule.
Myofibroblasts may participate in the capsular formation
of conventional and chromophobe RCCs through the
collagen production.
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