Publication:
Preterm birth and/or low birth weight are associated with periodontal disease and the increased placental immunohistochemical expression of inflammatory markers

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Pozo-31-231-237-2016-Corrected.pdf(3.88 MB)
Date
2016
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Authors
Pozo, Elena ; Mesa, Francisco ; Ikram, Mohamed H. ; Puertas, Alberto ; Torrecillas-Martínez, Laura ; Ortega-Oller, Inmaculada ; Magán-Fernández, Antonio ; Rodríguez-Martínez, María Dolores ; Padial-Molina, Miguel ; Sánchez-Fernández, Elena ; Galindo-Moreno, Pablo ; O’Valle, Francisco
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Publisher
Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
10.14670/HH-11-671
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info:eu-repo/semantics/article
Description
Abstract
The objective of this study was to determine whether gynecological and periodontal clinical parameters and the immunohistochemical expression in placental chorionic villi of the markers cyclooxygenase2 (COX-2), interleukin (IL)-1β, vascular endothelial growth factor receptor 1 (VEGFR1), podoplanin, and Heat Shock Protein (HSP70) are associated with preterm birth (PB) and/or low birth weight (LBW) neonates. Material and methods: An observational casecontrol study was performed in 130 puerperal women: mothers of PB/LBW neonates (cases, n=65) and mothers of full-term normal-weight neonates (controls, n=65). Data were gathered from all participants on sociodemographic, gynecological, and periodontal variables and on placental immunohistochemical COX-2, IL-1β, VEGFR1, podoplanin, and HSP70 expression. Results: Among the 42 women with mild/moderate periodontitis or gingivitis, the studied periodontal variables were significantly worse and the placental COX-2 (p=0.043), HSP70 (p=0.001), IL-1β (p=0.001), VEGFR1 (p=0.032), and podoplanin (p=0.058) expressions were significantly higher in the cases than in the controls. In comparison to the mothers without periodontitis, only COX-2 (p=0.026) and VEGFR1 (p=0.005) expressions were significantly increased in those with the disease. Increased COX-2 values were detected in the women with a history of genitourinary infection (p=0.036), premature rupture of membrane (p=0.012), or drug treatment (p=0.050). Conclusions: The etiology of preterm birth and/or low birth weight is multifactorial and involves consumption habits, social-health factors, and infectious episodes. These adverse pregnancy outcomes were associated with periodontitis and the increased placental expression of IL-1β, COX-2, VEGFR1, and HSP70.
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Cyclooxygenase 2 , Immunohistochemistry , Placenta , Chronic periodontitisperiodontitis , Gingivitis
Citation
Histology and Histopathology, vol.31, nº2, (2016)
URI
http://hdl.handle.net/10201/106442
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Histology and histopathology Vol.31, nº2 (2016)
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