Publication: lmmunohistological signposts in central nervous system tumours with neuronal differentiation
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Date
1991
Authors
Cruz-Sánchez, F. F. ; Rossi, M.L. ; Rodríguez-Prados, S. ; Cusi, V. ; Coakham, H.B.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
25 neuronal tumours with a panel of
antibodies were studied and it was found that vimentin
was present in 15 tumours. It was also found in a few cells
within rosettes. PGP 9.5 showed a somatic pattern of
staining with nuclear and perinuclear positivity in 23.
Neurofilament reactivity was found in 14. Retina1
S-antigen was detected only in one medulloblastoma,
314 pineal tumours and 212 retinoblastomas. Reactivity.
for synaptophysin was present in 215 medulloblastomas,
3/10 neuroblastomas and 212 retinoblastomas. GFAP
was demonstrated in scattered tumour cells in 415
medulloblastomas. Two of these were the only tumours
featuring bipolar differentiation whilst it was unipolar in
the remainder. The significance of these findings in
relation to the ontogeny of these tumours is discussed.
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Citation
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