Publication: lmmunofluorescent examination of the kidney post
mortem
Authors
Lászik, Z. ; Iványi, B. ; Ormos, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
106 selected kidneys removed at autopsy were
studied by direct immunofluorescence using polyvalent
antisera against human immunoglobulins, light chains,
complement fractions and fibrinogen. The
immunofluorescence was a suitable me'thod to solve
differential diagnostic problems that arose at autopsy. The
diagnostic value was the most obvious in cases of
immunologically mediated renal diseases and in
immunologically mediated systemic diseases involving the
kidneys. Negative immunofluorescence findings were also
useful to determine the pathogenesis of renal lesions,
especially in vasculopathies. The immunofluorescence of
postmortem material showed similar disturbances to that
obtained with biopsy material. At various sites, especially
in the tubulo-interstitium, additional electron microscopical
study was sometimes needed to localise the immune deposits
exactly. The fluorescent microscopical examination of
frozen sections of kidney taken at necropsy turned out to
be more adequate than the immunoperoxidase examination
of formalin-fixed, paraffin-embedded sections.
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Citation
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