Publication: The enhancing effect of excess retinol palmitate on induction of odontogenic tumors and inhibitory effect on squamous cell carcinoma of the gingiva in hamsters treated with N-methylnitrosourea
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Date
1999
Authors
Kohgo, T. ; Mezawa, F. ; lizuka, T. ; Shindoh, M.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The influence of excess retinol palmitate on
induction of tumors in the oral region was examined
histopathologically. Sixty-three weanling Syrian golden
hamsters were divided into five groups and received
either 0.2% N-methylnitrosourea (MNU) (lmg1100g
body weight) or retinol palmitate (RP) (25,000 IU/100g
body weight) twice a week for 16 weeks, singly or in
combination. Animals received RP intraperitoneally or
intragastrically and then, 6 hours later, the animals
received intragastric administration of MNU. To
accelerate the cell activity of the incisal tooth buds,
intentional disocclusion of the left upper and lower
incisor of all hamsters was carried out by repeated
cutting with cooled diamond disks to a level just above
the inter-dental papilla twice a week for 12 weeks. The
right incisors were left in occlusion. In all animals
exposed to RP+MNU, while the induction of squamous
cell carcinomas of the gingiva and forestomach were
prevented, the notable findings were a significantly
increased incidence of odontogenic tumors in cut incisal
regions of the animals with intragastric administration of
RP+MNU and an induction of maxillary neurogenic
tumors. The incidence of MNU-induced disturbances in
odontogenesis in the incisors was reduced but marked
disturbances were increased. RP seemed to have
opposite effects of prevention and enhancement for
development of neoplastic changes in the oral region.
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