Publication: Immunoelectron microscopy of human retroviruses
Authors
Timár, J. ; Lapis, K.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The ultrastructural detection and identification
of human retroviruses - HTLV (human T-cell
lymphotropic virus) and HIV (human immunodeficiency
virus) - have become an everyday task for pathologists
and virologists as well as for cell and molecular
biologists. The development of better and conventionally
available immunocytochemical techniques, such as preor
postembedding immunocytochemical methods,
cryofixation-variants and low temperature embeddings,
have made it possible to use them in this field. With the
help of these methods the structural proteins of HTLV-1
and HIV have been identified in infected cells. The virus
assembly at the cell membrane has also been described
in detail. Using these methods the incorporation
of human transplantation antigens into the envelope
of these viruses can be followed. Future studies
should establish the pathological significance of this
process.
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