Publication: Morhometric changes in GH-immunoreactive adenohypophyseal cells induced by intraventricular administration of colchicine to adult rats
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Date
1992
Authors
Carretero, J. ; Sánchez, F. ; Rubio, M. ; Juanes, J.A. ; Blanco, E. ; González, R. ; Riesco, J. M. ; Vázquez, R.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In order to elucidate whether the gender
differences observed in the somatotropic cells of adult
rats are mediated by hypothalamic neuropeptides, a
morphometric analysis was made of the GH-immunoreactive
cells of adult rats treated intraventricularly with
colchicine. The morphometric and morphological
findings obtained were correlated to the basal serum
levels of GH at the time of sacrifice. Treatment with
colchicine was seen to increase serum GH levels; this
increase was accompanied by an increase in the intensity
of the reaction of the GH-cells and, morphometrically,
an increase in their size due to an increase in the nuclear
area, but with no significant changes in the cytoplasmic
area. The results suggest that in the absence of
somatostatin and GRF the basal release of GH is
elevated in a similar fashion in both sexes, in turn
suggesting that gonadal steroids might act at
hypothalamic leve1 on the release of somatostatin and,
indirectly, on the intracellular pool of GH and hormonal
secretion.
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