Publication: Light microscopical morphometry of prolactin secreting adenomas under treatment with dopamine agonists
Loading...
Date
1987
Authors
Hamester, U. ; Saeger, W. ; Ludecke, D.K.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
In order to study the light microscopical
alterations of pituitary tumours under dopamine agonist
treatment, three groups of a total of 18 large or small cell
chromophobe adenomas were analysed by light
microscopical, immunohistological and morphometrical
methods.
They were all removed by transsphenoidal surgery. 6
of them were treated preoperatively with dopamine
agonists, bromocriptine andlor lisuride, for various
periods of time. 8 adenomas remained preoperatively
untreated. 4 additional untreated tumors were small cell
inactive adenomas for comparison. One case was
excluded from the final evaluation of the data because it
appeared to be a typical non-responder, clinically as well
as histologically.
Immunohistological positivity for prolactin was to be
found in all cases in various degrees. Clinically active
adenomas contained many prolactin positive cells,
whereas in inactive adenomas only scattered cells were
prolactin positive.
The morphometric analysis revealed a reduction of
the cytoplasmic area in a statistically significant degree in
the group of adenomas under treatment, which explains
adequately the shrinkage of the entire adenoma and the
reduction of prolactin plasma levels. The morphometric
data of treated adenomas resembled those of untreated
inactive adenomas.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.