Publication: Intraosseous squamous cell carcinoma associated with denosumab-induced osteonecrosis of the jaw
Authors
Bacián Martínez, Sandra ; Navarro Cuéllar, Carlos ; Navarro Vila, Carlos ; Palacios Weiss, Edurne ; Pujol Romanyá, Roser ; Amo Fernández de Velasco, Álvaro del ; Escrig de Teijeiro, Margarita ; Castillo Pardo de Vera, josé Luis del ; Rodríguez Pérez, Irene ; Sánchez Pérez, Arturo Joaquín ; Zamorano-León, José J. ; López-Farré, Antonio ; García-Hidalgo Alonso, María Isabel ; Navarro Cuéllar, Ignacio
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Facultad de Medicina
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Publisher
MDPI
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DOI
https://doi.org/10.3390/app11167646
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info:eu-repo/semantics/article
Description
Abstract
Medication-related osteonecrosis of the jaw (MRONJ) has been associated with the use of different drugs administered in the treatment of malignant neoplasms or metastases and in antiresorptive therapies. Since 2010, denosumab, a monoclonal antibody whose mechanism of action is to prevent the activation of the RANK receptor on the surface of osteoclasts, has been associated with osteonecrosis of the jaw. Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare neoplasm characterised by the presence of squamous cells within the maxillary or mandibular bone without an initial clinical association with the oral mucosa. We present a case of a PIOSCC in an osteonecrosis of the jaw related to a patient who received antiresorptive treatment with denosumab outlining the clinical and histopathological features of MRONJ and PIOSCC.
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Citation
Appl. Sci. 2021, 11, 7646
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