Publication: BMI-1: a protein expressed in stem cells, specialized cells and tumors of the gastrointestinal tract
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Date
2006
Authors
Reinisch, C. ; Kandutsch, S. ; Uthman, A. ; Pammer, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Recently, BMI-1 was identified as a protein
downregulating p16ink4a and mandatory for the
continued existence of several stem cell compartments
like hematopoietic and neural stem cells. In this study
we investigated BMI-1 expression as a potential stem
cell marker of the gastrointestinal tract. We found weak
expression in the isthmus region of the stomach, and
moderate expression in crypts of the intestines, whereas
intestinal surface epithelial cells were weakly positive or
negative for BMI-1. In addition, a variety of highly
differentiated cells such as parietal cells, neuroendocrine
cells of the pylorus, Paneth cells and a subset of goblet
cells were moderately to strongly positive for BMI-1.
Furthermore, we detected strong expression in
gastrointestinal neoplasias. This expression pattern
indicates a correlation of BMI-1 expression with
gastrointestinal stem cells as well as numerous
specialized cell types and points to a role of this protein
in cellular differentiation in addition to that of stem cell
maintenance. Besides, our results imply a role for BMI-1
in the tumorigenesis of gastrointestinal cancer.
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