Publication: Ultrasound-assisted enzymatic synthesis of xylitol fatty acid esters in
solvent-free conditions
Authors
Donaire, Antonio ; Villa Aroca, Rocío ; Lozano Rodríguez, Pedro ; Nieto Cerón, Susana
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Publisher
Elsevier
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DOI
https://doi.org/10.1016/j.ultsonch.2021.105606
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info:eu-repo/semantics/article
Description
© 2021 The Author(s). This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
This document is the Published Manuscript version of a Published Work that appeared in final form in Ultrasonics Sonochemistry. To access the final edited and published work see https://doi.org/10.1016/j.ultsonch.2021.105606
Abstract
A commercial immobilized lipase was successfully used for the synthesis of five xylityl acyl esters by means of the esterification of free fatty acids (caprylic, capric, lauric and myristic, respectively) with xylitol under solvent-free conditions. Ultrasound-assistance was shown to be a key tool to overcome the handicap imposed by both the mutual immiscibility of fatty acids and xylitol substrates, and the semisolid character of the initial reaction mixtures. In such semisolid systems, ultrasonic irradiation may enable the transport of substrate molecules to the enzyme catalytic-site, leading to the efficient synthesis of xylityl fatty ester (e.g. up to 95% yield after 90 min at 40ºC), with xylityl monoacyl ester and xylitol diacyl ester appearing as the main products (>96%), assessed by HPLC and NMR analyses. The separation of products was carried out by heating and simple centrifugation of the reaction medium, which was possible due to different densities of the resulting fractions.
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Citation
Ultrasonics Sonochemistry, 2021, Vol. 75 : 105606
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