Publication: The effects of PSK, a biological response
Authors
Matsui, H. ; Setogawa, T. ; Tanaka, Osamu
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The antiteratogenic effects of PSK, a
biological response modifier, were examined using
histological and developmental analysis. The whole
bodies of pregnant mice were irradiated with X-rays and
injected with PSK within ten minutes after irradiation on
day 7 of gestation (E7). The foetuses on E18 were
examined and a high incidence of malformations were
observed in X-ray irradiated embryos. Microphthalmia
was the most frequent malformation. PSK administration
suppressed the X-ray irradiation-induced ocular
anomalies in not only the frequency, as deduced by
external observation. but also in histopathological
changes in the retina, lens, and cornea. In particular. the
incidence of lens aplasia was significantly decreased by
PSK administration. Developmental analysis using E10
and E13 embryos revealed that the decrease in the
incidence of histopathological changes was first
observed within 72 hours after PSK administration. In
addition, X-ray irradiation-induced early foetal death
(E 1 O- 13) was also suppressed by PSK administration.
The possible mechanisms of the antiteratogenic effects
of PSK are discussed.
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