Publication: Complex and elementary histological
scoring systems for articular cartilage repair
Authors
Orth, Patrick ; Madry, Henning
item.page.secondaryauthor
item.page.director
Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
publication.page.editor
publication.page.department
DOI
https://doi.org/10.14670/HH-11-620
item.page.type
info:eu-repo/semantics/article
Description
Abstract
The repair of articular cartilage defects is
increasingly moving into the focus of experimental and
clinical investigations. Histological analysis is the gold
standard for a valid and objective evaluation of
cartilaginous repair tissue and predominantly relies on
the use of established scoring systems. In the past three
decades, numerous elementary and complex scoring
systems have been described and modified, including
those of O’Driscoll, Pineda, Wakitani, Sellers and
Fortier for entire defects as well as those according to
the International Cartilage Repair Society (ICRS-I/II) for
osteochondral tissue biopsies. Yet, this coexistence of
different grading scales inconsistently addressing diverse
parameters may impede comparability between reported
study outcomes. Furthermore, validation of these
histological scoring systems has only seldom been
performed to date. The aim of this review is (1) to give a
comprehensive overview and to compare the most
important established histological scoring systems for
articular cartilage repair, (2) to describe their specific
advantages and pitfalls, and (3) to provide valid
recommendations for their use in translational and
clinical studies of articular cartilage repair.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. CC BY 4.0