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Antioxidant enzymes in renal cell carcinoma

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dc.contributor.authorSoini, Y.es
dc.contributor.authorKallio, J.P.es
dc.contributor.authorHirvikoski, P.
dc.contributor.authorHelin, H.
dc.contributor.authorKellokumpu-Lehtinen, P.
dc.contributor.authorTammela, T.L.J.
dc.contributor.authorPeltoniemi, M.
dc.contributor.authorMartikainen, P.M.
dc.contributor.authorKinnula, V.L.
dc.date.accessioned2011-06-30T12:02:12Z
dc.date.available2011-06-30T12:02:12Z
dc.date.issued2006
dc.description.abstractThe aim of the study was to estimate the significance of oxidative/nitrosative damage and expression of antioxidant enzymes in renal cell carcinomas (RCC). For this we investigated immunohistochemically six antioxidant enzymes (AOEs) including MnSOD, ECSOD, thioredoxin, thioredoxin reductase, and gammaglutamyl cysteine synthetase heavy and light chain in 138 RCCs. As an indicator of oxidative/nitrosative damage, sections were stained with an antibody to nitrotyrosine. The extent of apoptosis was evaluated by TUNEL method and proliferation by immunohistochemistry to Ki67. Variable expression of all AOEs could be seen in RCC with expression of MnSOD being strongest. Nitrotyrosine was significantly associated with high grade tumors. MnSOD was associated with tumors of a lower stage. Cases showing ECSOD reactivity had higher and cases expressing thioredoxin lower apoptotic index than other tumors. No association with patient prognosis was observed. According to the results renal cell carcinomas show oxidative/nitrosative damage which, according to nitrotyrosine staining, was higher in high grade tumors. Of AOEs, MnSOD was more abundantly expressed in low stage tumors suggesting that its antioxidant function could play a main role to prevent development of oxidative damage leading to more aggressive tumors.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/22616
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCanceres
dc.subjectKidneyes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleAntioxidant enzymes in renal cell carcinomaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.21, nº 2 (2006)