Publication: Angiogenic factors and the endometrium following long term progestin only contraception
Authors
Lockwood, C.J. ; Schatz, F. ; Krikun, G.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Endometria from long term progestin only
contraceptive-treated patients display abnormally
enlarged blood vessels that are prone to bleeding as well
as inflammation and possibly local diminution in blood
flow. Such bleeding is also characterized by focal
reductions in the expression of angiopoietin-1, a vessel
stabilization and maturation agent, and excess
production of the potent angiogenic agents, vascular
endothelial growth factor and angiopoietin-2. In
addition, tissue factor, the key initiator of hemostasis
may play an angiogenic role either directly or via the
activation of thrombin. This review article summarizes
current findings related to the endometrial dysregulation
of angiogenic/hemostatic agents following treatment
with long term progestin only contraception. Studies in
this area offer a promising avenue to alleviate abnormal
uterine bleeding associated with this otherwise highly
effective form of contraception
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.