Publication: Transdifferentiation in neoplastic development and its pathological implication
Loading...
Date
2001
Authors
Zhang, Z. ; Yuan, X.M. ; Li, L.H. ; Xie, F.P.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Transdifferentiation is a process in which a
cell committed to a particular specialization changes to
another quite distinct type. It occurs during
embryological development and some pathological
processes, and causes the tumor cells to express a
phenotype different from that of their normal
progenitors. Neoplastic transdifferentiation involves
pathogenesis of cancer subtype, transition between
neoplastic epithelia and neuroendocrine cell, transition
between neoplastic epithelia and mesenchyme, as well as
transition between non-neuroectodermal and
neuroectodermal cells. We propose that differentiation
disturbance of cancer cells should include not only
lower-, un-, or de-differentiation, but also
transdifferentiation. Tumor cell transdifferentiation
results from genetic instabilities. In some type of
neoplastic transition, the initiation may be induced by
extracellular matrix and growth factors.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.