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A quantitative description of the insulin-induced ultrastructural changes in newborn rat hepatocytes

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dc.contributor.authorMaintas, D.B.es
dc.contributor.authorKotoulas, Othon B.es
dc.contributor.authorKotoulas, Angeliki O.
dc.date.accessioned2011-02-01T09:16:35Z
dc.date.available2011-02-01T09:16:35Z
dc.date.issued1993
dc.description.abstractThe effects of insulin on the ultrastructure of newborn rat hepatocytes were systernatically quantified at satisfactory statistical significance. Insulin prevented the normal postnatal increase in the total volume of lysosomes and the breakdown of glycogen inside these organelles. The lysosomal glycogen-hydrolysing enzyme, acid alpha 1,4 glucosidase was inhibited by the hormone. Insulin also prevented the normal postnatal increase in the total volume of peroxisomes, especially of the crystalloid core-devoid type. The hormone produced an increase in the area of cell membrane, due to the forrnation of many irregular folds of the cell surface. These results constitute good evidence for participation of lysosomes and peroxisomes in the overall glycogen degradation and or gluconeogenesis in the newborn rat hepatocytes.es
dc.formatapplication/pdfes
dc.format.extent8es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/18408
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectInsulines
dc.subjectNewborn rates
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::611 - Anatomíaes
dc.titleA quantitative description of the insulin-induced ultrastructural changes in newborn rat hepatocyteses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol. 8, nº 2 (1993)