Publication: A quantitative description of the insulin-induced ultrastructural changes in newborn rat hepatocytes
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Date
1993
Authors
Maintas, D.B. ; Kotoulas, Othon B. ; Kotoulas, Angeliki O.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The effects of insulin on the ultrastructure of
newborn rat hepatocytes were systernatically quantified
at satisfactory statistical significance. Insulin prevented
the normal postnatal increase in the total volume of
lysosomes and the breakdown of glycogen inside these
organelles. The lysosomal glycogen-hydrolysing
enzyme, acid alpha 1,4 glucosidase was inhibited by the
hormone. Insulin also prevented the normal postnatal
increase in the total volume of peroxisomes, especially
of the crystalloid core-devoid type. The hormone
produced an increase in the area of cell membrane, due
to the forrnation of many irregular folds of the cell
surface. These results constitute good evidence for
participation of lysosomes and peroxisomes in the
overall glycogen degradation and or gluconeogenesis in the newborn rat hepatocytes.
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Citation
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