Stereoselective synthesis of β-lactams: recent examples

Saura Sanmartín, Adrián; Andreu Ardil, Laura

Publication:
Stereoselective synthesis of β-lactams: recent examples

dc.contributor.advisor	Saura Sanmartín, Adrián
dc.contributor.author	Saura Sanmartín, Adrián
dc.contributor.author	Andreu Ardil, Laura
dc.contributor.department	Química Orgánica
dc.date.accessioned	2023-11-16T07:16:16Z
dc.date.available	2023-11-16T07:16:16Z
dc.date.copyright	© 2023 The Royal Society of Chemistry
dc.date.issued	2023-04-06
dc.description.abstract	The synthesis of β-lactam derivatives is a research topic of great interest due to the biological activity of these molecules. Indeed, there are several antibiotics which include a β-lactam core in their structures, such as penicilins, monobactams, carbacephems and cephamycins. The development of stereoselective approaches to access these molecular architectures turns out to be necessary in order to take advantage of the distinct properties provided by the different stereoisomers. This review covers recent advances towards the stereoselective synthesis of β-lactams, including Staudinger syntheses, cascade reactions, metal-catalyzed syntheses and base-promoted cyclizations. Within these methods, some particularly novel synthetic approaches are highlighted, such as the induction of chirality through bimetallic synergistic catalysis or the transfer of chirality between components in mechanically interlocked molecules. Additionally, a critical opinion on the state of the art of this research field is offered, remarking key points on which the future research should be focused on.	es
dc.format	application/pdf	es
dc.format.extent	11	es
dc.identifier.citation	Organic & Biomolecular Chemistry, 21, 2023, 3296-3306
dc.identifier.doi	https://doi.org/10.1039/D3OB00309D
dc.identifier.eissn	1477-0539
dc.identifier.issn	1477-0520
dc.identifier.uri	http://hdl.handle.net/10201/135741
dc.language	eng	es
dc.publisher	Royal Society of Chemistry	es
dc.relation	European Union – NextGenerationEU (Margarita Salas postdoctoral grant, Ministerio de Universidades of the Government of Spain)	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Attribution-NonCommercial 4.0 International	*
dc.rights.accessRights	info:eu-repo/semantics/openAccess
dc.rights.uri	http://creativecommons.org/licenses/by-nc/4.0/
dc.subject	β-lactams	es
dc.subject	Stereoselective synthesis	es
dc.subject.other	CDU::5 - Ciencias puras y naturales::54 - Química::547 - Química orgánica	es
dc.title	Stereoselective synthesis of β-lactams: recent examples	es
dc.type	info:eu-repo/semantics/article	es
dc.type.version	info:eu-repo/semantics/publishedVersion
dspace.entity.type	Publication	es
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